Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds
نویسندگان
چکیده
منابع مشابه
Bridging the gap between ribosomal and nonribosomal protein synthesis.
A minoacyl-tRNA synthetases (aaRSs) are the enzymes normally responsible for the attachment of amino acids (aa) to tRNAs. Numerous paralogous proteins of aaRSs have been identified in a wide range of organisms, but the functions of most of these aaRS-like proteins are yet to be determined. In PNAS, the study by Mocibob et al. (1) identifies a paralog of seryl-tRNA synthetase that does not amino...
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A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-ribosomal peptide aldehydes is presented. The method provides access to structurally diverse macrocycles by exploiting the reactivity of transient macrocyclic peptide imines toward inter- and intramolecular nucleophiles. Reactions are performed in aqueous media, in the absence of side chain protecting groups...
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ژورنال
عنوان ژورنال: Natural Product Reports
سال: 2009
ISSN: 0265-0568,1460-4752
DOI: 10.1039/b714132g